반응 #997880

반응 방정식

1-[2-(5-bromo-thiophen-2-yl)-pyridin-4-yl]-4-methyl-piperazine

copper(I) cyanide

EtOAc

→

title compound

5-[4-(4-Methyl-piperazin-1-yl)-pyridin-2-yl]-thiophene-2-carbonitrile

용매

DMF

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   세척The filtrate was washed with water
3. 3
   농축the organic layer was concentrated
4. 4
   기타The resulting residue was purified by preparative TLC

실험 절차

A mixture of 1-[2-(5-bromo-thiophen-2-yl)-pyridin-4-yl]-4-methyl-piperazine (41 mg, 0.13 mmol) and copper(I) cyanide (55 mg, 0.62 mmol) was heated in DMF at 180° C. by microwave for 30 minutes. After cooling, EtOAc was added and the resulting mixture was passed through Celite®. The filtrate was washed with water and the organic layer was concentrated. The resulting residue was purified by preparative TLC to yield the title compound.

출처