반응 #997190

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3-bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid phenyl ester

2-amino-4-chlorobenzenesulfonamide

BrCl

→

4-Bromo-6-tert-butyl-2-(6-chloro-1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-3-methylphenol

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후처리

1. 1
   기타obtained as white crystals

실험 절차

From 3-bromo-5-tert-butyl-6-hydroxy-2-methyl-benzoic acid phenyl ester and 2-amino-4-chlorobenzenesulfonamide; obtained as white crystals following column chromatography (silica gel/EtOAc-heptane-CH2Cl2 1:6:3); mp 270-271° C. (decomp., ebullition); 1H NMR (DMSO): δ 12.58 (s, 1H, NH), 9.64 (s, 1H), 7.91 (d, J=8.3 Hz, 1H), 7.55 (dd, J˜8.3, 1.9 Hz, 1H), 7.48 (s, 1H), 7.34 (d, J=1.9 Hz, 1H), 2.20 (s, 3H), 1.37 (s, 9H); LC-MS: m/z 457/459/461 (M+H; BrCl isotope pattern), 935/937/939/941 (2M+Na; Br2Cl2 isotope pattern); Rt=2.24 min.

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