반응 #9969

반응 방정식

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine

4-formylpyridine

magnesium sulfate

→

title compound

수율 100.7%

(±)-7-(Pyridin-4-yl)methyleneamino-1,2,3,5,6,7,8,8a-octahydroindolizine

수율 100.7%

용매

toluene

반응 조건

후처리

1. 1
   여과At the end of this time, the reaction mixture was filtered
2. 2
   기타to remove the catalyst
3. 3
   농축the filtrate was concentrated by evaporation under reduced pressure

실험 절차

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine (4.91 g (35.0 mmol), prepared as described in 1)) was dissolved in toluene (95 ml). To the solution were added 4-formylpyridine (3.34 ml, 35.0 mmol) and anhydrous magnesium sulfate (3.75 g, 31.2 mmol), and the resulting mixture was stirred at 70° C. for 3 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (8.08 g) as a pale yellow oil (yield quantitative).

출처