반응 #9968

반응 방정식

(±)-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one

ammonia ethanol

hydrogen

→

title compound

수율 98.0%

(±)-7-Amino-1,2,3,5,6,7,8,8a-octahydroindolizine

수율 98.0%

반응 조건

후처리

1. 1
   여과At the end of this time, the reaction mixture was filtered
2. 2
   기타to remove the catalyst
3. 3
   농축the filtrate was concentrated by evaporation under reduced pressure

실험 절차

(±)-1,2,3,5,6,7,8,8a-octahydroindolizin-7-one (5.0 g, 35.9 mmol) was dissolved in a solution of 2M ammonia/ethanol (54 ml, 108 mmol calculated in terms of ammonia). The resulting solution was stirred at room temperature in an atmosphere of hydrogen in the presence of 10% palladium on charcoal (500 mg) for 4 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (4.91 g) as a colorless oil (yield 98%).

출처