반응 #9962

반응 방정식

6-Amino-5-chloro-2-methylbenzoxazole

sulfuryl chloride

→

6-Amino-5,7-Dichloro-2-Methylbenzoxazole

용매

ethyl acetate

ethyl acetate

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   여과After 1 hour the precipitate was filtered off
3. 3
   세척washed with ether
4. 4
   기타air-dried

실험 절차

6-Amino-5-chloro-2-methylbenzoxazole (10 g, 54.76 mMole) was dissolved in ethyl acetate (150 mL). At room temperature and with good stirring, sulfuryl chloride (8.8 mL, 109.52 mMole) was added drop by drop over a 20-minute period. As the addition proceeds, additional ethyl acetate (350 mL) was added to keep the mixture stirring. After 1 hour the precipitate was filtered off, washed with ether and air-dried. Yield 10.5 g.

출처