반응 #993

반응 방정식

Chloroacetylchloride

2-aminopyridine

diisopropylethylamine

→

brown solid

수율 80.1%

2-Chloro-N-(2-pyridinyl)acetamide

수율 80.1%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타the temperature below 5° C
2. 2
   여과was filtered
3. 3
   세척washed with water
4. 4
   건조The organic layer was dried (MgSO4)
5. 5
   기타evaporated under reduced pressure

실험 절차

Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.

출처