반응 #992731

반응 방정식

N-[17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo-[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide

N-[17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl) sulfonamide

17-(4-bromo-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid

→

title product 66

N-[17-(4-bromo-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl) sulfonamide

반응 조건

실험 절차

The title product 66 was prepared from 17-(4-bromo-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.3.0.04,6]octadec-7-ene-4-carboxylic acid (65) following the same procedures described for the preparation of N-[17-(3-chloro-6-methoxyisoquinolin-1-yloxy)-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo-[13.3.0.04,6]octadec-7-ene-4-carbonyl](cyclopropyl)sulfonamide (43, Example 11): m/z=691 (M+H)+; 1H-NMR (CDCl3): 10.7 (br s, 1H), 8.09 (d, J=9.1 Hz, 1H), 7.3 (d, J=2.4 Hz, 1H), 7.25 (s, 1H), 7.15 (dd, J=9.1 Hz, 2.4, 1H), 7 (br s, 1H), 5.8 (br s, 1H), 5.74 (dd, J=18.2 Hz, 8, 1H), 5.16 (t, J=10.3 Hz, 1H), 4.74 (dd, J=9.3 Hz, 7, 1H), 4.05 (dd, J=11.1 Hz, 4, 1H), 3.95 (s, 3H), 3.6 (d, J=11.1 Hz, 1H), 3.1-3.2 (m, 1H), 2.9-3 (m, 1H), 2.83 (s, 3H), 2.4-2.5 (m, 3H), 2.19-2 (m, 2H), 2.5-2.7 (m, 4H), 1.4-1 (m, 3H), 1.2-1.35 (m, 2H), 1.05-1.15 (m, 1H), 0.95-1 (m, 1H).

출처