반응 #992706

반응 방정식

5-aminouracil

4,4′-difluorobenzophenone

→

N-(5-uracil-yl)-4,4′-difluorobenzophenone imine

용매

—

hexanes

N-methylpyrrolidone N-cyclohexylpyrrolidone

반응 조건

후처리

1. 1
   기타In a round bottom flask equipped with an overhead stirrer
2. 2
   workup.ADDITIONwas added to fully induce precipitation
3. 3
   기타the solid was isolated by filtration
4. 4
   기타twice recrystallized from isopropanol
5. 5
   세척The product was rinsed with isopropanol, suction
6. 6
   기타dried
7. 7
   기타vacuum dried in an oven overnight

실험 절차

In a round bottom flask equipped with an overhead stirrer, 1.16 grams (0.009 mole) of 5-aminouracil was charged along with 6 grams (0.027 mole) of 4,4′-difluorobenzophenone and a N-methylpyrrolidone/N-cyclohexylpyrrolidone solvent mixture (50/50, 20 milliliters). The reaction mixture was then heated to 180° C. for 3 days. A charge of hexanes (100 milliliters) was added to fully induce precipitation, and the solid was isolated by filtration and twice recrystallized from isopropanol. The product was rinsed with isopropanol, suction dried, and vacuum dried in an oven overnight.

출처