반응 #992256

반응 방정식

α-bromomethyl-2,4-dichlorobenzyl alcohol

2-(4-chlorobenzyloxymethyl)-3,4-dihydro-2H-pyran

→

trans-6-(4-chlorobenzyloxymethyl)-2-[2-bromo-1-(2,4-dichlorophenyl)ethoxy]tetrahydropyran

수율 69.2%

용매

diethyl ether

반응 조건

후처리

1. 1
   기타to react at room temperature for 4 days
2. 2
   workup.ADDITIONafter which it was treated
3. 3
   기타the product purified essentially

실험 절차

102 mg of α-bromomethyl-2,4-dichlorobenzyl alcohol and the 82 mg of 2-(4-chlorobenzyloxymethyl)-3,4-dihydro-2H-pyran prepared above were then dissolved in 2 ml of diethyl ether, and one drop of phosphorus oxytrichloride was then added. The mixture was then allowed to react at room temperature for 4 days, after which it was treated and the product purified essentially as described in Example 34(a), to give 121 mg of trans-6-(4-chlorobenzyloxymethyl)-2-[2-bromo-1-(2,4-dichlorophenyl)ethoxy]tetrahydropyran.

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