반응 #991802

반응 방정식

sulfuric acid

ammonium chloride

1-cyano-isoquinoline

4-chloro-bromobenzene

magnesium

→

1-(4-chlorobenzoyl)-isoquinoline

수율 76.6%

용매

ether

반응 조건

후처리

1. 1
   workup.ADDITIONis added
2. 2
   workup.WAITto stand for a night
3. 3
   기타After neutralization the ether phase is separated
4. 4
   workup.DISTILLATIONthe solvent is distilled off

실험 절차

To a solution of 3.1 g (20 millimoles) of 1-cyano-isoquinoline in anhydrous ether a Grignard reagent prepared from 5.75 g (30 millimoles) of 4-chloro-bromobenzene and 0.735 g (30 millimoles) of magnesium metal is added. The reaction mixture is allowed to stand for a night, thereafter the complex is decomposed with ammonium chloride solution, acidified with a 20% sulfuric acid and allowed to stand for 2 hours. After neutralization the ether phase is separated and the solvent is distilled off. 4.1 g (76.6%) of 1-(4-chlorobenzoyl)-isoquinoline are obtained.

출처