반응 #991361

반응 방정식

thiocarbohydrazide

3-ethoxypropionic acid

→

4-amino-5-(2-ethoxyethyl)-4H-1,2,4-triazole-3-thiol

용매

diethyl ether

반응 조건

후처리

1. 1
   온도heated
2. 2
   온도at reflux until solution
3. 3
   여과The crude white solid (94.6 g) when filtered
4. 4
   기타recrystallized from 1200 ml of water

실험 절차

63.6 g (0.6 mole) of thiocarbohydrazide and 100.0 g (0.85 mole) of 3-ethoxypropionic acid are stirred and heated at reflux until solution is achieved. The resultant solution is cooled to room temperature, diluted with 700 ml of diethyl ether and refrigerated for 1 hour. The crude white solid (94.6 g) when filtered and recrystallized from 1200 ml of water, gives 54.6 g of lustrous white plates of 4-amino-5-(2-ethoxyethyl)-4H-1,2,4-triazole-3-thiol. m.p. 123°-124° C.

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