반응 #989

반응 방정식

(R)-N-(2-pyridyl)-2-aminopropanol

N,N-diisopropylethylamine

thionyl chloride

→

(R)-4-methyl-3-(2-pyridyl)-[1,2,3] oxathiazolidine 2-oxide

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   기타was kept below 10° C
2. 2
   기타The organic phase was separated
3. 3
   세척washed with water (5×500 ml)
4. 4
   추출The aqueous phase was back-extracted with dichloromethane (2×500 ml)
5. 5
   건조dried (MgSO4)
6. 6
   기타evaporated in vacuo
7. 7
   기타to give a brown oil
8. 8
   기타This was purified on a silica column
9. 9
   세척eluting with diethyl ether

실험 절차

A solution of (R)-N-(2-pyridyl)-2-aminopropanol (20.0 g, 0.13 moles) and N,N-diisopropylethylamine (33.6 g, 0.13 moles) in dichloromethane (500 ml) was cooled to 5° C. Then thionyl chloride (15.5 g, 0.13 moles) in dichloromethane (100 ml) was added slowly whilst the temperature was kept below 10° C. The mixture was stirred for 0.5 h. and ice cold water (500 ml) was added. The organic phase was separated and washed with water (5×500 ml). The aqueous phase was back-extracted with dichloromethane (2×500 ml), the organic phases were combined, dried (MgSO4) and evaporated in vacuo to give a brown oil. This was purified on a silica column, eluting with diethyl ether to give (R)-4-methyl-3-(2-pyridyl)-[1,2,3] oxathiazolidine 2-oxide (154.4 g) as a clear oil.

출처