반응 #987635

반응 방정식

2-amino-5-phenyl-3-thiophenecarboxamide

trimethylsilyl isothiocyanate

N,N-Dimethylformamide

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product

수율 35.3%

(Aminothiocarbonyl)amino-5-phenyl-3-thiophenecarboxamide

수율 35.3%

용매

N,N-dimethylacetamide

반응 조건

후처리

1. 1
   기타The solvent was removed
2. 2
   기타the resulting slurry was chromatographed on silica gel eluting with isohexane

실험 절차

A solution of 2-amino-5-phenyl-3-thiophenecarboxamide (1.09 g, 5 mmol) and trimethylsilyl isothiocyanate (0.85 ml, 6 mmol) in N,N-dimethylacetamide was stirred at 75° C. for 7 days. N,N-Dimethylformamide was added until solution. The solvent was removed and the resulting slurry was chromatographed on silica gel eluting with isohexane followed by methylene chloride and diethyl ether to give the product as a yellow solid (0.49 g, 35%).

출처