반응 #987565

반응 방정식

sulphamic acid

4-(5-nitrothiazol-yl-azo)-N-butyl-N-(2-cyanomethoxycarbonylethyl)aniline

2-amino-5-nitrothiazole

propionic acid

Nitrosyl sulphuric acid

→

4-(5-nitrothiazol-yl-azo)-N-butyl-N-(2-cyanomethoxy-carbonylethyl)aniline

용매

water

acetone

acetone

acetic acid

반응 조건

후처리

1. 1
   기타After one hour the product was isolated by filtration
2. 2
   세척washed with cold water
3. 3
   기타dried
4. 4
   기타to yield

실험 절차

2-amino-5-nitrothiazole (2.9 parts) was set stirring at 5° C. with a mixture of acetic acid and propionic acid, 86:14 (50 parts). Nitrosyl sulphuric acid 40% (7.0 parts) was added below 5° C. and the mixture was stirred for 30 mins. The diazo solution was added gradually to a stirred coupling mixture of N-butyl, N-2(cyanomethoxycarbonylethyl)-aniline (5.2 parts), acetone (50 parts), water (200 parts) and sulphamic acid (0.5 parts). After one hour the product was isolated by filtration, washed with cold water and dried to yield, 4-(5-nitrothiazol-yl-azo)-N-butyl-N-(2-cyanomethoxycarbonylethyl)aniline (2.9 parts) λmax=571 nm (acetone).

출처