반응 #987054

반응 방정식

HCl

N-hexylbenzylamine

(4-{[2-(Methoxycarbonyl)benzyl]oxy}phenyl)acetic acid

EDC

→

Methyl 2-[(4-{2-[benzyl(hexyl)amino]-2-oxoethyl}phenoxy)methyl]benzoate

용매

water

DCM

반응 조건

후처리

1. 1
   기타The two phases were separated
2. 2
   여과Filter Tube
3. 3
   기타The obtained organic solution was evaporated in vacuum
4. 4
   workup.WAITthe oil product (71 mg) was left

실험 절차

(4-{[2-(Methoxycarbonyl)benzyl]oxy}phenyl)acetic acid (50 mg, 0.166 mmol) was dissolved in DCM (2 ml), N-hexylbenzylamine (38.2 mg, 0.2 mmol) was added, then EDC (38.3 mg, 0.2 mmol) was added and then DMAP (24.4 mg, 0.2 mmol) was added. The mixture was stirred at room temperature overnight. 1% HCl (1 ml) and water (1 ml) were added into the mixture. The two phases were separated by using a Whatman Filter Tube. The obtained organic solution was evaporated in vacuum and the oil product (71 mg) was left. It was then used directly in next step.

출처