반응 #9869

반응 방정식

sodium carbonate

3-bromo-N-[2-(1-pyrrolidinyl)ethyl]phenylcarboxamide

3-formylphenylboric acid

→

3′-Formyl-N-[2-(1-pyrrolidinyl)ethyl][1,1′-biphenyl]-3-carboxamide

용매

water

toluene

ethanol

반응 조건

후처리

1. 1
   추출extracted with diethyl ether
2. 2
   세척The extract was washed with brine
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   기타The solvent was evaporated under reduced pressure, whereby the title compound (6.83 g)
5. 5
   기타was obtained

실험 절차

Palladium tetrakistriphenyl phosphine (735 mg) and 2 M aqueous sodium carbonate (21.2 ml) were added to a solution of 3-bromo-N-[2-(1-pyrrolidinyl)ethyl]phenylcarboxamide (6.31 g) in toluene (50 ml), and then a solution of 3-formylphenylboric acid (3.49 g) in ethanol (15 ml) was added thereto, and the mixture was stirred at 90° C. for 15 hours. The reaction solution was diluted with water and then extracted with diethyl ether. The extract was washed with brine and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, whereby the title compound (6.83 g) was obtained.

출처