반응 #985883

반응 방정식

CH3COONa

2,4-dichloro-6-methyl-5-propyl-pyrimidine

→

6-methyl-5-propyl-pyrimidine

2-chloro-6-methyl-5-propyl-pyrimidine

4-chloro-6-methyl-5-propyl-pyrimidine

용매

EtOAc

반응 조건

후처리

1. 1
   기타is then hydrogenated at 50 psi overnight
2. 2
   여과The catalyst is filtered
3. 3
   기타the solvent is removed in vacuo

실험 절차

5% Pd/C (25 mg) and CH3COONa (820 mg, 10 mmol) are added to a solution of 2,4-dichloro-6-methyl-5-propyl-pyrimidine (1.02 g, 5 mmol) in EtOAc (25 ml). The mixture is then hydrogenated at 50 psi overnight. The catalyst is filtered and the solvent is removed in vacuo. Flash column chromatography of the residue on silica gel by 4:1 hexane, EtOAc provides 2-chloro-6-methyl-5-propyl-pyrimidine (LC-MS, M+1 171.7), 4-chloro-6-methyl-5-propyl-pyrimidine (LC-MS, M+1 171.7) and 6-methyl-5-propyl-pyrimidine (LC-MS, M+1 157.7) as 1:1:1.5 mixture, which is separated by HPLC.

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