반응 #985327
ord-f07cb4c8e2b444a2ad2eedeaf712b641
반응 방정식
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide
sodium trimethylsilanolate
→
title compound
6-Chloro-1-methylcarbamoylmethyl-1H-indole-3-carboxylic acid
시약
없음
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1농축the mixture was concentrated in vacuo
- 2기타purified by prep
실험 절차
2-[6-Chloro-3-(2,2,2-trifluoro-acetyl)-indol-1-yl]-N-methyl-acetamide was suspended in DCE and treated with (2.2 eq.) of sodium trimethylsilanolate. After shaking at room temperature for 20 min, the mixture was concentrated in vacuo and purified by prep. HPLC to give the title compound.