반응 #985261

반응 방정식

4-nitrobenzoyl chloride

2-aminothiophenol

→

product

수율 73.2%

2-(4-Nitrophenyl)benzothiazole

수율 73.2%

용매

benzene

반응 조건

후처리

1. 1
   기타The reaction was quenched with water (20 mL)
2. 2
   기타The aqueous layer was separated
3. 3
   추출extracted with ethyl acetate (3×10 ml)
4. 4
   기타The combined organic layers were dried
5. 5
   기타evaporated
6. 6
   기타The crude product was purified
7. 7
   기타with flush column, (hexane:ethyl acetate=85:15)

실험 절차

A solution of 4-nitrobenzoyl chloride (1.49 g, 8.0 mmol) in benzene anhydrous, 10 mL) was added dropwise to 2-aminothiophenol (1.0 g, 8.0 mmol in 10 ml of benzene) at room temperature. The reaction mixture was allowed to stir for 16 hr. The reaction was quenched with water (20 mL). The aqueous layer was separated and extracted with ethyl acetate (3×10 ml). The combined organic layers were dried and evaporated. The crude product was purified with flush column, (hexane:ethyl acetate=85:15) to give 1.5 g (73.2%) of product as light yellow solid.

출처