반응 #985252

반응 방정식

chlorotrimethylsilane

neopentyl alcohol

1-methylimidazole

→

2,2-dimethyl-1-trimethylsilyloxypropane

수율 85.8%

반응 조건

후처리

1. 1
   기타Removal of the upper phase

실험 절차

6.50 g (56.7 mmol) of chlorotrimethylsilane were added dropwise while stirring at 0° C. to a solution of 5.00 g (56.7 mmol) of neopentyl alcohol (2,2-dimethyl-1-propanol) and 11.6 g (142 mmol) of 1-methylimidazole. The reaction mixture was stirred at 0° C. for a further 2 h and at 20° C. for 2.5 h. Removal of the upper phase gave 7.80 g (theory: 9.09 g) of 2,2-dimethyl-1-trimethylsilyloxypropane as a colorless oil having a purity of 96% (GC).

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