반응 #985250

반응 방정식

chlorotrimethylsilane

1-butanol

1-methylimidazole

→

1-trimethylsilyloxybutane

수율 89.4%

반응 조건

후처리

1. 1
   기타to form a liquid biphasic mixture
2. 2
   기타Removal of the upper phase

실험 절차

4.40 g (40.5 mmol) of chlorotrimethylsilane were added dropwise while stirring at 0° C. to a solution of 3.00 g (40.5 mmol) of 1-butanol and 11.1 g (135 mmol) of 1-methylimidazole. The reaction mixture was stirred at from 0 to 5° C. for a further 15 min and at 20° C. for 15 min to form a liquid biphasic mixture. Removal of the upper phase gave 5.30 g (theory: 5.93 g) of 1-trimethylsilyloxybutane as a colorless oil having a purity of 90% (GC).

출처