반응 #980253

반응 방정식

1-chloro-4-(4-acetamidophenyl)-2-oxo-3-butene

hydrazinecarbothioic acid O-methylester

→

5-[2-(4-acetamidophenyl)ethanyl]-5,6-dihydro-1,3,4-thiadiazin-2(3H)one

용매

toluene

반응 조건

후처리

1. 1
   온도was refluxed for 3 h
2. 2
   여과The crystals were filtered
3. 3
   세척washed with toluene

실험 절차

A mixture containing 4.0 g of 1-chloro-4-(4-acetamidophenyl)-2-oxo-3-butene (J. Org. Chem., 28, 2446, 1963) and 2.3 g of hydrazinecarbothioic acid O-methylester in 150 ml of toluene was refluxed for 3 h. The crystals were filtered and washed with toluene. Yield 3.0 g (65%), mp. 235°-240° C.

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