반응 #979338

반응 방정식

2-methyl-6,8-difluoroquinoline

2-Methyl-6,8-difluoroquinoline

benzoyl peroxide

N-bromosuccinamide

→

title compound

6,8-Difluoroquinolin-2-ylmethyl bromide

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   온도to reflux for 18 hours
2. 2
   농축The reaction is concentrated
3. 3
   기타the resulting residue purified by column chromatography (silica, 3:1 CH2Cl2

실험 절차

A solution of 2-methyl-6,8-difluoroquinoline (0.147 g, 0.820 mmoles, Example 26a), benzoyl peroxide (9.93 mg, 0.0410 mmoles), and N-bromosuccinamide (0.168 g, 0.943 mmoles) in carbon tetrachloride (20 mL) is heated to reflux for 18 hours. The reaction is concentrated and the resulting residue purified by column chromatography (silica, 3:1 CH2Cl2:hexane, then CH2Cl2) to yield the title compound as a white solid. MS (ESI) 258, 260 (M+H)+, Br pattern.

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