반응 #9779

ord-6955e06f343f4d48a5b3006d7249844a

반응 방정식

COC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
COC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
intermediate 132
COC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
CC(C)S
isopropylthiol
→
CC(C)SCc1cc(-c2ccc(C(F)(F)F)cc2)sc1CO
title compound
CC(C)SCc1cc(-c2ccc(C(F)(F)F)cc2)sc1CO
{5-[4-(trifluoromethyl)phenyl]-3-[(isopropylthio)methyl]thien-2-yl}methanol

반응물

COC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
COC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
intermediate 132
COC(=O)c1sc(-c2ccc(C(F)(F)F)cc2)cc1CBr
methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate
CC(C)S
isopropylthiol

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared using methyl 3-(bromomethyl)-5-[4-(trifluoromethyl)phenyl]thiophene-2-carboxylate (intermediate 132) and isopropylthiol.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07091237B2uspto-grants-2006_08