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2-[2-(7-chloro-thieno[3,2-b]pyridin-2-yl)-thiazol-4-yl]-propan-2-ol

1-methyl-5-trifluoromethyl-1H-pyrazol-3-ol

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title compound

수율 8.0%

2-{2-[7-(1-Methyl-5-trifluoromethyl-1H-pyrazol-3-yloxy)-thieno[3,2-b]pyridin-2-yl]-thiazol-4-yl}-propan-2-ol

수율 8.0%

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실험 절차

The title compound (11 mg, 8%) was prepared from 2-[2-(7-chloro-thieno[3,2-b]pyridin-2-yl)-thiazol-4-yl]-propan-2-ol and 1-methyl-5-trifluoromethyl-1H-pyrazol-3-ol by a procedure analogous to Example 16. C18H15F3N4O2S2: APCI m/z 441.3 (pos.); 1H NMR (CD3OD): δ 8.53 (d, 1H, J=5.6 Hz), 7.91 (s, 1H), 7.48 (s, 1H), 7.07 (d, 1H, J=5.6 Hz), 6.68 (s, 1H), 3.98 (s, 3H), 1.61 (s, 6H) ppm.

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