반응 #975236

반응 방정식

compound 18a

6-hydroxy-5-methoxyindanone

35b

Ethyl 3-(3-hydroxy-4-methoxyphenyl)acrylate

→

5-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one

반응 조건

후처리

1. 1
   기타Isolated as light brown powder in 67%
2. 2
   기타overall yield (3.55 g)

실험 절차

5-Hydroxy-6-methoxy-2,3-dihydro-1H-inden-1-one 18b was prepared from 35b V according to the protocol described for the preparation of compound 18a in Example 33 (Scheme 11). Isolated as light brown powder in 67% overall yield (3.55 g). 1H NMR (300 MHz, CDCl3): δ 2.69 (2H, m); 3.03 (2H, m); 3.92 (3H, s); 4.28 (1H, broad s); 6.92 (1H, s); 7.17 (1H, s). 13C NMR (75 Hz, CDCl3): δ 24.65; 35.86; 55.05; 103.68; 111.00; 127.98; 147.67; 151.32; 153.72; 206.88.

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