반응 #973026

반응 방정식

3-chloro-5-fluoro-benzonitrile

1-methyl-piperazine

K2CO3

→

3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile

수율 65.8%

용매

DMF

반응 조건

후처리

1. 1
   여과The resulting slurry was filtered
2. 2
   기타the solvent was removed in vacuo

실험 절차

A mixture of 3-chloro-5-fluoro-benzonitrile (1 g, 6.45 mmol), 1-methyl-piperazine (0.715 ml, 6.45 mmol), and K2CO3 (2.64 g, 19.3 mmol) in DMF (5 ml) was heated to 140° C. for 40 min in a microwave apparatus. The resulting slurry was filtered and the solvent was removed in vacuo to give 1 g of 3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile. The crude reaction mixture was used in the next step without any further purification.

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