반응 #973

반응 방정식

N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine

N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

sodium methoxide

→

N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

용매

methanol

반응 조건

후처리

1. 1
   온도while cooling by means of an ice bath
2. 2
   온도The mixture is then heated
3. 3
   온도to reflux for 2 hours
4. 4
   workup.STIRRINGwhile stirring

실험 절차

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

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