반응 #9723
ord-ac4f6997785540cfabd1e40607d0df66
반응 방정식
반응물
시약
없음
반응 조건
온도
40°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타The organic layer was collected
- 2세척washed twice with water and brine
- 3건조dried over sodium sulfate
- 4여과filtered
- 5농축the filtrate concentrated
실험 절차
A solution of ethyl 2-(4-acetyl-2-methylphenoxy)-2-methylpropanoate (intermediate 8, 37.33 g) in dichloromethane (650 ml) was treated with 4-toluenesulphonic acid (2.75 g) followed by m-chloroperbenzoic acid (60.5 g) and the mixture warmed to 40° C. and stirred under nitrogen for 19 hours. The cooled mixture was treated with dichloromethane (350 ml) and the resulting mixture added to aqueous potassium iodide (1000 ml, 10% solution). The organic layer was collected and washed twice with water and brine, then dried over sodium sulfate, filtered and the filtrate concentrated to give the title compound as an orange oil.