반응 #971552

ord-732bb75812624ef5b62364cbb81a5139

반응 방정식

CC(C)(O)C[C@]1(c2ccccc2)CCN([C@H]2CCCNC2)C(=O)O1
(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one
CC(C)(C)NC(=O)c1cnc(Br)s1
2-bromo-N-tert-butylthiazole-5-carboxamide
→
CC(C)(O)C[C@]1(c2ccccc2)CCN([C@H]2CCCN(c3ncc(C(=O)NC(C)(C)C)s3)C2)C(=O)O1
title compound
CC(C)(O)C[C@]1(c2ccccc2)CCN([C@H]2CCCN(c3ncc(C(=O)NC(C)(C)C)s3)C2)C(=O)O1
N-tert-butyl-2-((S)-3-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)piperidin-1-yl)thiazole-5-carboxamide

반응물

CC(C)(O)C[C@]1(c2ccccc2)CCN([C@H]2CCCNC2)C(=O)O1
(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one
CC(C)(C)NC(=O)c1cnc(Br)s1
2-bromo-N-tert-butylthiazole-5-carboxamide

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-piperidin-3-yl)-1,3-oxazinan-2-one and 2-bromo-N-tert-butylthiazole-5-carboxamide following a procedure analogous to that described in Example 13. LC-MS Method 2 tR=1.23 min, m/z=515.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08242111B2uspto-grants-2012_08