반응 #971356

반응 방정식

N-{6-[4-(piperazine-1-carbonyl)phenoxy]-pyridin-3-yl}-4-trifluoromethyl-benzamide

1,2-epoxycyclohexane

→

N-(6-{4-[4-((1S,2S)-2-hydroxy-cyclohexyl)piperazine-1-carbonyl]phenoxy}pyridin-3-yl)-4-trifluoromethylbenzamide

용매

methanol

반응 조건

후처리

1. 1
   온도under reflux
2. 2
   기타The resulting reaction solution
3. 3
   농축was concentrated under reduced pressure
4. 4
   기타The residue was purified by silica gel column chromatography (chloroform:methanol=35:1)
5. 5
   workup.ADDITIONethyl acetate was added
6. 6
   여과The precipitated white powder was filtered off
7. 7
   세척washed with ethyl acetate

실험 절차

To a solution of N-{6-[4-(piperazine-1-carbonyl)phenoxy]-pyridin-3-yl}-4-trifluoromethyl-benzamide (430 mg, 0.91 mmol) in methanol was added 1,2-epoxycyclohexane (180 mg, 1.83 mmol), and the resulting solution was stirred for 1 day under reflux. The resulting reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol=35:1), and then ethyl acetate was added. The precipitated white powder was filtered off and washed with ethyl acetate, to thereby yield 284 mg of the title compound.

출처