반응 #969905

반응 방정식

1,4-diazabicyclo[3.2.2]nonane

1-fluoro-4-nitrobenzene

ethylene glycol diethyl ether

→

4-(4-Nitro-phenyl)-1,4-diaza-bicyclo[3.2.2]nonane hydrofluoric acid salt

용매

diethyl ether

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   여과The mixture was filtered
3. 3
   기타the product was isolated by filtration

실험 절차

A mixture of 1,4-diazabicyclo[3.2.2]nonane (20.2 g, 160 mmol), 1-fluoro-4-nitrobenzene (17.5 ml, 163.3 mmol) and ethylene glycol diethyl ether (160 ml) was stirred at 135° C. for 18 hours. The mixture was cooled to room-temperature and diethyl ether (100 ml) was added. The mixture was filtered and the product was isolated by filtration. Yield 24.8 g (58%). Mp. 122-129° C.

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