반응 #969834

반응 방정식

4-methylbenzenesulphonic acid benzyl beta-alaninate

4-nitrophenyl chlorocarbonate

→

benzyl N-[(4-nitrophenoxy)carbonyl]-beta-alaninate

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도the reaction mixture was then heated
2. 2
   온도to reflux for 30 min
3. 3
   농축Subsequently, the reaction mixture was concentrated under reduced pressure
4. 4
   기타the residue was purified by means of preparative HPLC
5. 5
   건조After concentration of the corresponding fractions and drying of the residue under high vacuum, 86 mg (44% of theory) of the title compound
6. 6
   기타were obtained

실험 절차

200 mg (0.57 mmol) of commercially available 4-methylbenzenesulphonic acid-benzyl beta-alaninate and 229 mg (1.14 mmol) of 4-nitrophenyl chlorocarbonate were taken up in 15 ml of tetrahydrofuran and the reaction mixture was then heated to reflux for 30 min. Subsequently, the reaction mixture was concentrated under reduced pressure and the residue was purified by means of preparative HPLC. After concentration of the corresponding fractions and drying of the residue under high vacuum, 86 mg (44% of theory) of the title compound were obtained.

출처