반응 #967216

반응 방정식

3-hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride

Intermediate 17

3-hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride

cis-4-phenylcyclohexanamine

Intermediate 14

cis-4-phenylcyclohexanamine

Et3N

→

3-hydroxy-2-oxo-N-(cis-4-phenylcyclohexyl)-1,2-dihydropyridine-4-carboxamide

용매

DCM

반응 조건

후처리

1. 1
   기타The reaction mixture was partitioned between H2O and DCM
2. 2
   건조The DCM layer was dried over Na2SO4
3. 3
   여과filtered through a silica gel plug
4. 4
   기타The solvent was removed under reduced pressure
5. 5
   기타to give Example 36A which
6. 6
   기타was used without further purification

실험 절차

To a solution of 3-hydroxy-2-oxo-1,2-dihydropyridine-4-carbonyl chloride (Intermediate 17) (38.1 mg, 0.219 mmol) and cis-4-phenylcyclohexanamine (Intermediate 14) (50 mg, 0.29 mmol) in DCM (1 mL) was added Et3N (0.061 mL, 0.44 mmol). The reaction mixture was stirred at rt for 1 h. The reaction mixture was partitioned between H2O and DCM. The DCM layer was dried over Na2SO4 and filtered through a silica gel plug. The solvent was removed under reduced pressure to give Example 36A which was used without further purification.

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