반응 #967

반응 방정식

3-(N-tert-butyloxycarbonylaminomethyl) azetidine

N-benzyloxycarbonyl-O-methylisourea

→

title compound

수율 38.5%

3-(N-tert-butyloxycarbonylaminomethyl)-1-(N-benzyloxycarbonylamidino) azetidine

수율 38.5%

용매

toluene

반응 조건

후처리

1. 1
   기타Evaporation

실험 절차

0.9 g (4.8 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl) azetidine and 1.3 g (6.3 mmol) of N-benzyloxycarbonyl-O-methylisourea was mixed in 6.5 mL toluene and heated to 70° C. for 72 h and then left at room temperature for another 72 h. Evaporation followed by flash chromatography using EtOAc followed by MeOH (saturated with NH3 (g))/CH2 Cl2, 1/9, as eluent gave 0.67 g (38%) of the title compound as a white powder.

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