반응 #9669

반응 방정식

Sulfuryl chloride

5-fluoro-1,3-benzothiazole-2-thiol

→

2-Chloro-5-fluoro-1,3-benzothiazole

반응 조건

후처리

1. 1
   온도heated at 60° C. for 30 minutes
2. 2
   온도The resulting solution was cooled to rt
3. 3
   workup.ADDITIONpoured onto ice
4. 4
   여과The title compound was collected by filtration
5. 5
   세척washed with water
6. 6
   기타dried under vacuum
7. 7
   기타The solid obtained
8. 8
   기타was used without further purification

실험 절차

Sulfuryl chloride (50 μL, 0.65 mmol) was added neat to 5-fluoro-1,3-benzothiazole-2-thiol (100 mg, 0.54 mmol). The mixture was stirred at ambient temperature for 1 h, then heated at 60° C. for 30 minutes. The resulting solution was cooled to rt, and poured onto ice. The title compound was collected by filtration, washed with water, and dried under vacuum. The solid obtained was used without further purification; LC-MS m/z 188.1 (MH+), ret. time 3.27 min.

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