반응 #966780

반응 방정식

(S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyrimidin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate

1-(3-propyl)-piperazine

1,4-dioxane

→

(S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-5-methyl-2-(2-(4-(pentan-3-yl)piperazin-1-yl)pyrimidin-4-yl)benzo[d]thiazol-6-yl)acetate

반응 조건

후처리

1. 1
   workup.WAIT40° C. for 1 h
2. 2
   기타Upon completion of the reaction
3. 3
   여과the reaction mixture was filtered through Celite (ethyl acetate eluent)
4. 4
   농축concentrated
5. 5
   기타used without further purification

실험 절차

To (S)-methyl 2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2-chloropyrimidin-4-yl)-5-methylbenzo[d]thiazol-6-yl)acetate (40.0 mg, 0.077 mmol) was added 1-(3-propyl)-piperazine (60.5 mg, 0.387 mmol) in 1,4-dioxane (1 mL). The reaction mixture was stirred at room temperature for 20 min, then 40° C. for 1 h. Upon completion of the reaction, the reaction mixture was filtered through Celite (ethyl acetate eluent), concentrated, and used without further purification. LCMS-ESI+ calc'd for C34H43ClN5O3S (M+H+): 636.3; Found: 636.2 (M+H+).

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