반응 #966670

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(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-cyclopropyl-1-methyl-1H-indazol-5-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

5-bromo-2,3-dimethyl-2H-indazole

→

(S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(2,3-dimethyl-2H-indazol-5-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid

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실험 절차

prepared in a similar manner as the preparation of (S)-2-tert-butoxy-2-(7-(4-chlorophenyl)-2-(3-cyclopropyl-1-methyl-1H-indazol-5-yl)-5-methylbenzo[d]thiazol-6-yl)acetic acid except using 5-bromo-2,3-dimethyl-2H-indazole instead of 5-bromo-3-cyclopropyl-1-methyl-1H-indazole. LCMS-ESI+: calc'd for C29H28ClN3O3S: 534.2, 536.2 (M+H+); Found: 534.2, 536.2 (M+H+). 1H NMR (400 MHz, CD3OD): δ 8.37 (s, 1H), 7.99 (dd, J=9.1, 1.7 Hz, 1H), 7.82 (s, 1H), 7.76-7.66 (m, 1H), 7.66-7.50 (m, J=9.1, 4.8 Hz, 4H), 5.26 (s, 1H), 4.12 (s, 3H), 2.71 (s, 3H), 2.62 (s, 3H), 0.99 (s, 9H).

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