반응 #966

반응 방정식

3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine

→

title compound

수율 67.1%

3-(N-tert-butyloxycarbonylaminomethyl) azetidine

수율 67.1%

용매

MeOH

반응 조건

후처리

1. 1
   여과The catalyst was filtered off
2. 2
   기타the solvent evaporated
3. 3
   기타The crude product was purified by flash chromatography

실험 절차

3.4 g (9.6 mmol) of 3-(N-tert-butyloxycarbonylaminomethyl)-1-benzhydryl azetidine was dissolved in 170 mL MeOH and hydrogenated over 0.30 g Pd(OH)2 at 5 MPa over night. The catalyst was filtered off and the solvent evaporated. The crude product was purified by flash chromatography using MeOH/CH2Cl2, 1/9, followed by MeOH (saturated with NH3 (g))/CH2Cl2, 1/9, as eluent to yield 1.2 g (67%) of the title compound.

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