반응 #963810
ord-13fc18d5454a463e883265f119a8e1be
반응 조건
온도
0°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1세척washed with 1N HCl, saturated NaHCO3 aq., H2O, and brine
- 2건조dried over anhydrous Na2SO4
- 3기타The solvent was removed under reduced pressure
- 4기타The resulting residue was purified by silica gel column chromatography (Hexane/EtOAc=7/3)
- 5기타to obtain compound aa28-1 (8.02 g) as pale yellow oil
실험 절차
A mixture of 2-iodophenol (6 g), 3-hydroxy-3-methylbutyl tosylate (7.4 g) and Cs2CO3 (13.3 g) in DMF (120 mL) was stirred at 0° C. for 2 h and at room temperature for 10 h. The mixture was diluted with EtOAc and washed with 1N HCl, saturated NaHCO3 aq., H2O, and brine, and dried over anhydrous Na2SO4. The solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography (Hexane/EtOAc=7/3) to obtain compound aa28-1 (8.02 g) as pale yellow oil.