반응 #9638

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cis-2-(4-bromobenzoyl)cyclopropanecarboxylic acid

2,2-dimethoxypropane

HCl

→

methyl cis-2-(4-bromobenzoyl)-cyclopropanecarboxylate

수율 99.7%

용매

MeOH

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후처리

1. 1
   기타evaporated to dryness
2. 2
   기타The resulting residue was purified by flash chromatography (Biotage Flash 40M)

실험 절차

To a solution of cis-2-(4-bromobenzoyl)cyclopropanecarboxylic acid (10.6 g, 36.63 mmol) in MeOH (250 mL) was added 2,2-dimethoxypropane (9.54 g, 91.59 mmol) and HCl (4.0 M in dioxane, 3.50 mL). The resulting solution was stirred at 40° C. for 3 days, and then evaporated to dryness. The resulting residue was purified by flash chromatography (Biotage Flash 40M) using 15 to 25% ethyl acetate in hexanes to afford methyl cis-2-(4-bromobenzoyl)-cyclopropanecarboxylate (10.34 g, 99%). 1H NMR (400 MHz, CD2Cl2) δ 1.39 (m, 1H), 1.82 (m, 1H), 2.34 (m, 1H), 2.77 (m, 1H), 3.54 (s, 3H), 7.65 (m, 2H), 7.89 (m, 2H).

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