반응 #963

반응 방정식

lithium aluminium hydride

water

NaOH

water

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

→

product

수율 99.0%

(3RS)-1-benzyl-3-aminoethyl pyrrolidine

수율 99.0%

용매

diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   workup.ADDITIONwas added to the mixture
2. 2
   건조The slurry was dried from excess of water with Na2SO4 /cellite
3. 3
   여과filtered by suction
4. 4
   기타evaporated

실험 절차

14.7 g (0.0734 mole) (3RS)-1-benzyl-3-cyanomethyl pyrrolidine dissolved in 220 ml diethyl ether was slowly added to a slurry of 2.94 g of lithium aluminium hydride in 74 ml diethyl ether under an argon atmosphere. The mixture was stirred over night,and 6 ml water, 18 ml 3.75M NaOH-solution and 6 ml water was added to the mixture. The slurry was dried from excess of water with Na2SO4 /cellite, filtered by suction and evaporated to yield 14.84 g (99%) of the product.

출처