반응 #96241

반응 방정식

t-butyl 2-bromo-3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide

→

2-bromo-3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid-1-oxide

수율 101.5%

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   기타after evaporation to dryness under vacuo, 20 ml of 1,2-dichloroethane
2. 2
   workup.ADDITIONwere added to the residue
3. 3
   기타The evaporation to dryness
4. 4
   workup.ADDITION5 ml of ether and 50 ml of heptane were added to the residue
5. 5
   여과filtered
6. 6
   기타dried under vacuo

실험 절차

1.2 g of t-butyl 2-bromo-3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylate-1-oxide were stirred in 8 ml of trifluoroacetic acid over 15 minutes and after evaporation to dryness under vacuo, 20 ml of 1,2-dichloroethane were added to the residue. The evaporation to dryness was repeated and 5 ml of ether and 50 ml of heptane were added to the residue. The obtained product was vacuum filtered and dried under vacuo to obtain 1.1 g of 2-bromo-3-bromomethyl-7-phenoxyacetamido-3-cephem-4-carboxylic acid-1-oxide as almost colorless crystals.

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