반응 #96240

반응 방정식

t-butyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide

→

3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide

수율 102.2%

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   기타the solvent was removed by evaporation under vacuo
2. 2
   workup.ADDITIONAfter addition of 100 ml of 1,2-dichloroethane, evaporation to dryness
3. 3
   workup.ADDITIONEther was added to the residue
4. 4
   여과filtered
5. 5
   세척washed with ether
6. 6
   기타dried under vacuo

실험 절차

A solution of 37.3 g of t-butyl 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylate-1-oxide in 130 ml of trifluoroacetic acid was stirred for 15 minutes at room temperature and then the solvent was removed by evaporation under vacuo. After addition of 100 ml of 1,2-dichloroethane, evaporation to dryness was repeated. Ether was added to the residue and the crystals were vacuum filtered, washed with ether and dried under vacuo to obtain 33.7 g of 3-bromomethyl-7-phenylacetamido-3-cephem-4-carboxylic acid-1-oxide as an almost colorless solid having the following characteristics:

출처