반응 #96236

반응 방정식

t-butyl 3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide

→

3-bromomethyl-7-formamido-3-cephem-4-carboxylic acid-1-oxide

수율 99.6%

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   기타after evaporation to dryness under vacuo, 25 ml of dichloromethane
2. 2
   workup.ADDITIONwere added to the residue and evaporation to dryness
3. 3
   workup.ADDITIONEther was added to the residue
4. 4
   여과filtered
5. 5
   세척washed with ether
6. 6
   기타the almost colorless solid was dried under vacuo

실험 절차

10 g of t-butyl 3-bromomethyl-7-formamido-3-cephem-4-carboxylate-1-oxide in 40 ml of trifluoroacetic acid were stirred for 15 minutes at room temperature and after evaporation to dryness under vacuo, 25 ml of dichloromethane were added to the residue and evaporation to dryness was repeated. Ether was added to the residue and the formed crystals were vacuum filtered and washed with ether and the almost colorless solid was dried under vacuo to obtain 8.54 g of 3-bromomethyl-7-formamido-3-cephem-4-carboxylic acid-1-oxide having the following characteristics:

출처