반응 #962059

반응 방정식

aniline

2-amino-6-(trifluoromethyl)-benzoic acid trihydrate

→

2-amino-N-phenyl-6-trifluoromethyl-benzamide

용매

THF

반응 조건

후처리

1. 1
   기타The reaction
2. 2
   여과filtered
3. 3
   농축The filtrate was concentrated in vacuo
4. 4
   기타purified by flash chromatography

실험 절차

2-amino-N-phenyl-6-trifluoromethyl-benzamide was prepared by addition of aniline (1.0 eq.) to a suspension of 2-amino-6-(trifluoromethyl)-benzoic acid trihydrate (1.0 g, 4.0 mmol, 1.3 eq.) and polystyrene-carbodiimide (3.6 g, 1.1-1.7 eq.) in THF (40 mL). The reaction, was stirred at ambient temperature for 18 hours, then filtered. The filtrate was concentrated in vacuo and purified by flash chromatography to provide 2-amino-N-phenyl-6-trifluoromethyl-benzamide as a yellow solid.

출처