반응 #962002

반응 방정식

N-(2-(1,3-dioxolan-2-yl)ethyl)-N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethanamine

1-methyl-1,4-cyclohexadiene

→

title compound

수율 91.0%

N-(2-(1,3-Dioxolan-2-yl)ethyl)-2-((tert-butyldimethylsilyl)oxy)ethanamine

수율 91.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도The suspension was heated
2. 2
   온도at reflux for 30 minutes
3. 3
   온도to cool
4. 4
   여과The suspension was filtered through celite
5. 5
   세척the filter cake washed with further ethanol
6. 6
   기타The solvent was evaporated at reduced pressure

실험 절차

To a stirred solution of N-(2-(1,3-dioxolan-2-yl)ethyl)-N-benzyl-2-((tert-butyldimethylsilyl)oxy)ethanamine (3.87 g, 10.6 mmol) in ethanol (100 mL) was added 10% palladium on carbon (1.93 g) and 1-methyl-1,4-cyclohexadiene (5.93 mL, 53.0 mmol). The suspension was heated at reflux for 30 minutes and allowed to cool. The suspension was filtered through celite and the filter cake washed with further ethanol. The solvent was evaporated at reduced pressure to afford the title compound (2.64 g, 91%).

출처