반응 #962001

반응 방정식

2-((2-(1,3-dioxolan-2-yl)ethyl)(benzyl)amino)ethanol

imidazole

tert-butyldimethylsilyl chloride

→

N-(2-(1,3-Dioxolan-2-yl)ethyl)-N-benzyl-2-((tert-butyldimethylsilyl)oxy)-ethanamine

용매

DMF

ethyl acetate

반응 조건

후처리

1. 1
   세척washed with water and brine
2. 2
   건조The organic phase was dried (magnesium sulfate)
3. 3
   여과filtered
4. 4
   기타the solvent evaporated art reduced pressure (3.87 g, 95%)

실험 절차

To a stirred solution of 2-((2-(1,3-dioxolan-2-yl)ethyl)(benzyl)amino)ethanol (2.81 g, 11.2 mmol) in DMF (10 mL) was added imidazole (1.67 g, 24.61 mmol) and tert-butyldimethylsilyl chloride (3.35 g, 22.39 mmol). The reaction mixture was stirred at RT for 18 hours. The reaction mixture was diluted with ethyl acetate and washed with water and brine. The organic phase was dried (magnesium sulfate), filtered and the solvent evaporated art reduced pressure (3.87 g, 95%).

출처