반응 #962

반응 방정식

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

수율 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

수율 92.0%

용매

dimethyl sulfoxide

반응 조건

후처리

1. 1
   추출the mixture was extracted three times with ethyl acetate
2. 2
   세척The combined organic layer was washed with brine
3. 3
   건조dried (Na2SO4)
4. 4
   여과filtered
5. 5
   기타evaporated

실험 절차

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

출처