반응 #96052

반응 방정식

4-[4-chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol

→

4-[4-Chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenylimino-4-thiazoline

용매

acetic acid

반응 조건

후처리

1. 1
   기타Obtained by a procedure analogous to
2. 2
   workup.DISTILLATIONsubsequently distilling off the solvent
3. 3
   workup.ADDITIONWater is added to the residue
4. 4
   여과The crystals are filtered off
5. 5
   기타recrystallized from isopropanol

실험 절차

Obtained by a procedure analogous to that indicated in Example 2(b), from 4-[4-chloro-3-(1-methyl-4-piperazinylsulfonyl)-phenyl]-3-methyl-2-phenyliminothiazolidin-4-ol, by boiling with glacial acetic acid and subsequently distilling off the solvent. Water is added to the residue and the pH is adjusted to 13 with 2 N NaOH. The crystals are filtered off and recrystallized from isopropanol. Melting point 156°-158° C.

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